Postdoctoral Fellow Immunometabolism

TU Braunschweig

Who are we
The Department of Bioinformatics and Biochemistry (head: Prof. Dr. Karsten Hiller) dedicates its research to understand the role of
metabolism during disease development. We are interested in both, the metabolic adaptations of immune cells during inflammation,
and the metabolism of microorganisms during an infection. To determine the metabolic phenotype, we apply and develop analytical
and computational technologies centered around mass spectrometry (MS) and stable-isotope labeling. Our department is located in
the Braunschweig Integrated Centre of Systemsbiology (BRICS). BRICS is a joint center of the Technische Universit├Ąt and the Helmholtz
Center for Infection Research (HZI). BRICS aims to apply interdisciplinary research to investigate molecular mechanisms in infection

The Job
We are interested to investigate how metabolism is involved in the regulation of the innate immune response and how metabolic targets
can be exploited to modulate the immune response in macrophages. To profile the metabolism of immune cells and their mitochondria,
we apply modern technology such as stable-isotope (13C) tracing, mass-spectrometry, metabolic flux analysis, respiration measurements
and metabolomics. In addition, our team develops and employs all algorithms and computer programs required for the analysis of high
dimensional mass-spectrometric data.

Your profile
PhD in Immunology, Biochemistry, Molecular Biology or equivalent, experience with mammalian immune cells (in vitro primary cells and
cell lines), proficient in written and spoken English, strong team player

Job conditions
Temporary contract for three years, salary according to 100% E13 TV-L, start date: as soon as possible


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